A prospective randomized comparison of the accuracy of computer-assisted versus GUSTO nomogram--directed heparin therapy
Journal
Clin Pharmacol Ther
Publication Date
1994 May
Volume
55
Issue
5
Pages
591-6
Summary:
- HIT Description: Computerized decision support. More info...
- Purpose of Study: Evaluate computer-assisted heparin therapy for patients with myocardial infarction treated with recombinant TPA.
- Years of study: Not Available
- Study Design: RCT
- Outcomes: Impact on patient safety, Impact on health care effectivness/quality
- Settings: Fifty-one patients at 2 medical centers in Michigan participated in the study.
- Intervention: Computer-assisted heparin therapy to achieve and maintain therapeutic anticoagulation was compared to the GUSTO (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) heparin nomogram guidelines.
- Evaluation Method: Measures of anticoagulation.
- Description: The dosage in the computer-assisted heparin therapy was determined by using a Bayesian forecasting computer program from Therapeutic Technologies, Lansing, Michigan.
- Quality of Care and Patient Safety Outcome: Ninety-four percent of the APTT ratios in the computer group were equal to or greater than 1.5 in the first 24 hours compared with 78% in the GUSTO group (p