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An intelligent and cost-effective computer dosing system for individualizing FK506 therapy in transplantation and autoimmune disorders

Authors

McMichael J, Lieberman R, Doyle H, McCauley J, Fung J, Starzl TE

Journal

J Clin Pharmacol

Publication Date

1993 Jul

Volume

Issue

Pages

599-605

HIT Description: Decision support and computerized medication dosing. More info...
Years of study: 1990-Not available
Study Design: Evaluate an intelligent dosing system (IDS) for FK506 in autoimmune patients.
Outcomes: Impact on patient safety, Impact on health care effectivness/quality

Summary:

Settings: Fifty autoimmune patients from the University of Pittsburgh Presbyterian Medical Center, Pennsylvania participated in the study.
Intervention: An intelligent dosing system (IDS) for FK506 in predicting doses to achieve target drug levels in autoimmune patients.
Evaluation Method: Measures of IDS's accuracy and precision.
Quality of Care and Patient Safety Outcome: The accuracy of the IDS was -0.022 ng/mL (95% confidence interval = 0.011- -0.055) in the autoimmune patients. The precision of the IDS was 0.1188 ng/mL in the autoimmune patients.

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