Evaluation of drug interaction software to identify alerts for transplant medications
Journal
Ann Pharmacother
Publication Date
2005 Jan
Volume
39
Issue
1
Pages
45-50
Summary:
- HIT Description: decision support-clinical guidelines / protocols More info...
- Purpose of Study: evaluate the effectiveness of a common drug interaction software database to identify clinically important interactions involving transplant drugs
- Years of study: Not Available
- Study Design: other predictive analysis
- Outcomes: impact on healthcare effectiveness and quality
- Intervention: utilized an expert panel of 2 physicians and one pharmacist specializing in transplant to identify a list of drug interactions and rate their clinical significance
- Evaluation Method: compare the expert-derived list of interactions for certain drugs with the interactions identified by the software
- Description: Drug-Drug Interaction Module Version 3.2, by First DataBank (a drug interaction database)
- Quality of Care and Patient Safety Outcome: The database had low sensitivity and failed to identify approximately 70% of the interactions considered clinically significant by the expert panel and primarily missed interactions resulting from additive toxicity. 85% of the alerts generated by the database were clinically significant