This information is for reference purposes only. It was current when produced and may now be outdated. Archive material is no longer maintained, and some links may not work. Persons with disabilities having difficulty accessing this information should contact us at: https://digital.ahrq.gov/contact-us. Let us know the nature of the problem, the Web address of what you want, and your contact information.
Please go to digital.ahrq.gov for current information.

Evaluation of drug interaction software to identify alerts for transplant medications

Authors

Smith, W. D., Hatton, R. C., Fann, A. L., Baz, M. A., Kaplan, B.

Journal

Ann Pharmacother

Publication Date

2005 Jan

Volume

Issue

Pages

45-50

HIT Description: decision support-clinical guidelines / protocols More info...
Purpose of Study: evaluate the effectiveness of a common drug interaction software database to identify clinically important interactions involving transplant drugs
Years of study: Not Available
Study Design: other predictive analysis
Outcomes: impact on healthcare effectiveness and quality

Summary:

Intervention: utilized an expert panel of 2 physicians and one pharmacist specializing in transplant to identify a list of drug interactions and rate their clinical significance
Evaluation Method: compare the expert-derived list of interactions for certain drugs with the interactions identified by the software
Description: Drug-Drug Interaction Module Version 3.2, by First DataBank (a drug interaction database)
Quality of Care and Patient Safety Outcome: The database had low sensitivity and failed to identify approximately 70% of the interactions considered clinically significant by the expert panel and primarily missed interactions resulting from additive toxicity. 85% of the alerts generated by the database were clinically significant

The information on this page is archived and provided for reference purposes only.